Compared to NC, the genes expressed in the hippocampal tissue of the Donepezil rats were significantly related to neuroactive ligand-receptor interaction (p = 0.00308635), PI3K-Akt signalling pathway (p = 0.03017463), African trypanosomiasis (p = 0.03127858), and Malaria (p = 0.04276662), as shown in Figure 8D and Table 1B. The FC values of neuroactive ligand–receptor interaction-related genes in Donepezil rats, Npy2r, Chrm5, Trhr, and Rxfp1, were 2.20, 1.58, 1.60, and −2.12, respectively. Here, TRHR is linked to human African trypanosomiasis.