The cytokines act as the main mediators of various innate immunity pathways, such as TLR, TNF, and JAK/STAT signaling pathways, which have also been demonstrated to be enriched in the bladders of IC/BPS patients, especially in the context of chemotaxis of inflammatory cells [12,13,14]. The gene discussed is SOAT1; the disease is Bartsocas-Papas syndrome 1.