TLR4 and Alzheimer disease: Mutations in pattern-recognition receptors (PRRs) have been observed to be related to AD; these include polymorphisms in toll-like receptors (TLRs)—TLR2, TLR4, TLR6, TLR9—and gene polymorphisms in nucleotide-binding oligomerization domain-like receptors (NLRs)—CARD4, CARD12, CARD15, NALP1, NALP12, and NOD1; several SNPs of the human β-defensin 1 (DEFB1) gene have also been found in AD patients [19].