Mutations in genes (SRSF2, SF3B1, ZRSR2, U2AF1, ZXRSR2, SF1, and SF3A1) that encode the spliceosomal proteins are the most frequent recurrent mutations in MDS cases [37,38] identified in 30.1% of cases [31]. This evidence concerns the gene U2AF1 and myelodysplastic syndrome.