FLT3, IDH1 and IDH2, TP53 genes, co-mutation of TET2 and SRSF2 genes, increased VAF for TP53, DNMT3A, TET2, and NPM1 genes mutations, and the presence of ACA may be considered important markers for the leukemic transformation of MDS. This evidence concerns the gene TP53 and myelodysplastic syndrome.