A recent study suggested that DNMT3A gene mutations tend to be associated with transformation into leukemia (HR = 1.516; p = 0.098) [54], and it showed that increased DNMT3A VAF was associated with poor survival [54] underlying the predictive usefulness of DNMT3A mutational VAF for the prognostic assessment of MDS. This evidence concerns the gene DNMT3A and leukemia.