The HFD-induced obesity-related proteins showed significant enrichment in the expected pathways, such as Hypoxia-Inducible Factor (HIF)1α signaling, extracellular-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling, the production of NO and ROS in macrophages, the sirtuin signaling pathway, and the apelin adipocyte signaling pathway (Figure 5A). Here, MAPK1 is linked to obesity disorder.