The upregulation of peroxiredoxin-5 (PRDX5) as well as the downregulation of laminin subunit alpha-4 (LAMA4), long-chain fatty acid transport protein 1 (S27A1), and heat shock 70 kDa protein 12A (HS12A) can help counteract obesity-related IR. The gene discussed is HSPA12A; the disease is obesity due to melanocortin 4 receptor deficiency.