In fact, there is robust evidence that the activation of the immune-inflammatory reaction system and/or the compensatory immune-regulatory system might play an important role in the pathophysiology of major depressive and bipolar disorders [40], which are considered by their elevated production of various cytokines, including interleukin (IL)-6, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α [41]. This evidence concerns the gene TNF and bipolar disorder.