However, patient analysis based on the clinical division according to MM stage revealed that the above observation was primarily assigned to the RRMM group, where patients with percentages of CD4+PD-1+ T cells over the median value had markedly shorter TTP compared to those with a lower frequency of these cells (p = 0.033) (Figure 4a); of note, such an association was not shown for NDMM patients (p = 0.41) (Figure 4a). This evidence concerns the gene CD4 and Miyoshi myopathy.