For example, 88% of all severe asthma patients included in the International Severe Asthma Registry (ISAR) had at least one positive biomarker, 59% had double positivity, and 27% were triple positive (cut-offs were AEC ≥ 300/μL, FeNO ≥ 25 ppb and IgE ≥ 75 kU/l) [153]. The gene discussed is IGHE; the disease is asthma.