As previously described by our group, the antiproliferative activity of Roy-Bz in colon cancer cells was associated with the activation of a PKCδ-dependent mitochondrial apoptotic pathway, inducing mitochondrial reactive oxygen species (ROS) production, mitochondrial membrane potential (∆ψm) dissipation, and cytochrome c (cyt c) release to the cytosol [16]. The gene discussed is CYCS; the disease is colonic neoplasm.