In addition, the fluorescence immunoassay results showed that compared with the DHT group, the expression of β-catenin in DHT+ Exo-miR-122-5p was upregulated, and was similar to control group, illustrating that Exo-miR-122-5p enhanced the growth of HFs even after the treatment with high DHT concentrations (Figure 6D), and it also down-regulated the expression of SMAD3 (Figure 6E). Here, SMAD3 is linked to Hand-foot syndrome.