In turn, proteins from resistant T. cacao genotypes that were positively accumulated during infection were those involved in the response to oxidative stress, such as peroxidases, SOD and APX; proteins involved in defense such as PRs, HSPs and protease inhibitors, as well as proteins that have been shown to act directly in inhibiting fungal growth such as TcPHYLL, cystatins, legumains, TcPR-4b and TcPR-10 are strong candidates for functional biotechnological studies. This evidence concerns the gene CST4 and infection.