Mankaney et al. described in a retrospective study APC pathogenic variants in patients with and without upper gastrointestinal involvement affected by FAP; his group found an APC pathogenic variant to 5′ codon 1309 in 89% of patients with gastric cancer and sessile gastric polyps, with a cluster between codons 1061 and 1150 [17]. Here, APC is linked to gastric cancer.