The novel findings of this study are summarized as follows: (1) it was proven, for the first time, that HPF has the potential to promote the differentiation of BMSCs into HLCs, while the combination of HPF and HGF can significantly improve the differentiation efficiency of BMSCs; (2) HPF significantly improved the homing efficiency of BMSCs in the injured liver; (3) after treatment with BMSCs and HPF, the liver function and the morphology of the liver injury were improved considerably; (4) after treatment with BMSCs and HPF, the symptoms of ALI were vastly reduced. The gene discussed is HGF; the disease is acute respiratory distress syndrome.