DNER and central nervous system cancer: H3K27M mutation has a crucial impact on the epigenetic landscape of glioma: (i) a wide decrease in H3 trimethylation (H3K27Mme3) resulting in chromatin de-condensation; (ii) a simultaneous increase in H3K27Mac, a mark recognized by BET proteins to recruit RNA polymerase II and activate transcription (Figure 2) [191,192].