SSD, in combination with radiation (2 Gy), mediates powerful anti-cancer effects by inducing G-0/G-1 arrest, by upregulating p53 and Bax expression, and by downregulating Bcl2 expression under hypoxia exposure in SMMC-7721 hepatocellular carcinoma cells [43]. The gene discussed is BCL2; the disease is hepatocellular carcinoma.