During IMQ-induced skin inflammation, the expression of AIM2 inflammasome components, such as AIM2, ASC, and pro-caspase-1, in skin lesions is upregulated [21,40], and serum levels of IL-17A, a cytokine which has been implicated in the pathogenesis of psoriasis, are increased [41,42,43,44,45]. Here, CASP1 is linked to psoriasis.