VHL and nonpapillary renal cell carcinoma: In clear cell RCC (ccRCC, 80% of cases), the mutation of the tumor-suppressor von Hippel–Lindau (VHL) gene; chromosome remodeling by PBRM1, BAP1 and SETD2 genes; hyperactivated PI3K/AKT pathways; and mTOR alterations are the main molecular features [7,8,9,10].