CRP and rheumatoid arthritis: Compared to young-onset RA (YORA), EORA patients are more likely to be male and seronegative for rheumatoid factor (RF) and anti-cyclic citrullinated protein (CCP) antibodies, and have markedly elevated C-reactive protein (CRP) levels and erythrocyte sedimentation rates, suggesting that EORA and YORA have a different pathophysiology [4,5,6].