In the study of factors favoring progression from AIN1 to HSIL-plus in patients with AIDS, no statistically significant association was found in bivariate analyses, which considered age, age at start of sexual relations, number of sexual partners in previous 12 months, VPH vaccination, time since HIV diagnosis, CD4 count, CD8 count, viral load, and number of HR and LR HPV genotypes and of all genotypes. The gene discussed is CD4; the disease is AIDS.