Of the most significant coding variants associated with increased risk of glaucoma medication non-adherence, following Bonferroni correction (Table 3), SNPs rs2830585 (ADAMTS5), rs10888267 (OR2W3), rs16973457 (SAXO2), rs3795969 (KCTD18), rs2272487 (CHCHD6), and rs6741212 (UPK1A) were identified by the more conservative measure PDC80 (Table 3). The gene discussed is KCTD18; the disease is glaucoma.