Notably, exposure of heat-inactivated Planococcus citreus to peripheral blood mononuclear cells (PBMCs) resulted in heightened production of TNF-α, IL-1β, and IL-6 from monocytes, indicating that the enriched Planococcus in circulation may play a role in inflammation in SLE [49]. Here, IL1B is linked to systemic lupus erythematosus.