The major results of our high-multiplexing autoantibody screening of 55 plasma samples from SSc patients and 52 controls by means of antigen arrays showed 11 autoantibodies with increased prevalence in SSc patients compared to controls, eight of which bound to fibrosis-associated proteins: PIP4K2B, VEGFB, AKT2, AKT3, SMAD2, SERPINB13, IL31, and CTGF. This evidence concerns the gene PIP4K2B and systemic sclerosis.