On a target level, while our study included the major autoantibodies used for diagnosis of SSc, future studies should also complement these data with the evaluation of positivity for other autoantibodies reported to be associated with SSc (such as anti-U3RNP, anti-fibrillarin, anti-Th/To, anti-PmScl, anti-RNA polymerase III, anti-Ku, anti-PmScl, and anti-U1RNP antibodies). This evidence concerns the gene TH and systemic sclerosis.