NFKBIZ and neoplasm: Moreover, the amplification of the NFKBIZ locus has been observed in ~10% of ABC DLBCL cases [114], and NFKBIZ mutations affecting 3’UTR can stabilize the NFKBIZ transcript and lead to the overexpression of the IκBζ protein, which activates the NF-κB signaling pathway and provides a selective advantage to tumor cells [115,116].