MAPK3 and malignant colon neoplasm: In accordance, we previously reported that Lebein, a heterodimeric disintegrin isolated from Macrovipera lebetina snake venom, significantly inhibited the viability of LS174 colon cancer cells and induced their apoptosis by triggering the activation of the MAPK ERK1/2 pathway through the induction of reactive oxygen species (ROS) [44].