These properties contribute to the complexity of the neoplastic disease and are orchestrated by a network of cellular signaling pathways, such as Mitogen-activated protein kinase (MAPK), Phosphoinositide 3-kinase/Protein Kinase B (PI3K/AKT), Nuclear factor (NF)-κB, Janus kinase/Signal transducer and activator of transcription (JAK/STAT), Wingless-related integration site (Wnt)/β-catenin, Transforming growth factor-β (TGF)-β and Neurogenic locus notch homolog protein (Notch). The gene discussed is TGFB1; the disease is neoplasm.