Mechanistically, CRC-derived multiple sEV-miRNAs synergistically induced TAM M2-like polarization to promote the inhibition of CD8+ T lymphocytes by expressing PD-L1 through the PTEN/AKT and SOCS1/STAT1 signaling pathways; they thus contribute to immune escape and CRC progression [162]. This evidence concerns the gene AKT1 and colorectal carcinoma.