One of the markers of cancer progression and other pathologies is the appearance or upregulation of several keratin genes, including K17, K19, K6/16, etc. Keratins are not only routinely used for cancer diagnostics, but are also applicable for the prediction of invasiveness and aggressiveness of the tumor cell [242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259]. The gene discussed is KRT19; the disease is cancer.