Previous studies have demonstrated that DUSP6 is associated with many types of cancer and plays different roles; for example, DUSP6 regulates tumor suppression through ERK1/2 negative feedback in pancreatic cancer, lung cancer, ovarian cancer and nasopharyngeal carcinoma; on the contrary, DUSP6 plays an oncogenic role in human glioblastoma, thyroid cancer, breast cancer, and acute myeloid leukemia [29]. This evidence concerns the gene DUSP6 and breast cancer.