However, many alterations found in the heart of Cdkl5 +/− mice are also present in the RTT mouse model, Mecp2-null mice [48,95,96], and/or in RTT patients [97,98,99], suggesting that similar molecular alterations may underlie the cardiac dysfunctions in these conditions, with several overlapping phenotypic features. Here, CDKL5 is linked to Rett syndrome.