Notably, the relationship between CD73 and epithelial-to-mesenchymal transition is a central aspect of cancer metastasis, and preliminary findings suggest that CD73 may serve as a prognostic marker due to its role in promoting epithelial to mesenchymal transition progression, particularly in lung adenocarcinoma and triple-negative breast cancer [89,92]. Here, NT5E is linked to triple-negative breast carcinoma.