S-glutathionylated GAPDH is also found in tissues following ischemia reperfusion or chronic neurodegenerative disease [1,18,19,20], and S-glutathionylated GAPDH in blood samples from patients with Alzheimer’s disease (but not healthy controls) was elevated and this correlates with severity and disease progression [21]. The gene discussed is GAPDH; the disease is early-onset autosomal dominant Alzheimer disease.