Bronchiectasis were significantly more frequent in patients with COPD-OSA overlap syndrome than in those with COPD without OSA (43 vs. 19%) Furthermore, the co-presence of bronchiectasis and OSA in COPD patients was related to more severe nocturnal hypoxia, evaluated through the percentage of time spent with SpO2 below 90%, and higher systemic inflammation, according to through C-reactive protein levels [60]. The gene discussed is CRP; the disease is bronchiectasis.