Furthermore, by mimicking in vitro the neuropathy condition, in particular about inflammation and oxidative stress leading to an imbalance of ion transport, data revealed that the combination of PEA 80mesh with Equisetum A.L. seems to be able to repair the damage on the myelin sheath that protects the axon and simultaneously be able to act on NGF release and bind the p75 neurotrophin receptor, reproducing the mechanism of analgesia observed in humans. This evidence concerns the gene NGF and neuropathy.