Similarly, transcriptomic profiling of tumor-infiltrating neoantigen-reactive T cells of gastrointestinal cancer patients delineated an exhausted phenotype in the majority of CD8+ and CD4+ neoantigen-reactive TILs and showed that GPR56 was up-regulated significantly in CD4+ neoantigen-reactive TILs [134]. The gene discussed is CD8A; the disease is neoplasm.