In these cancers, precancerous lesions, atypical adenomatous hyperplasia, gastric dysplasia, sessile serrated adenoma/polyp with dysplasia (SSA/P-D), atypical endometrial hyperplasia, cervical intraepithelial neoplasia (CIN), and borderline malignant lesions display increased expression and/or abnormal distribution of CLDN4 [69,70,71,72,73,74]. The gene discussed is CLDN4; the disease is cancer.