Through activating mutations, gene amplifications, or rearrangements in PIK3CA and receptor tyrosine kinases or inactivating mutations in tumor suppressor genes, the PI3K/AKT/mTOR pathway, which regulates cell metabolism, proliferation, apoptosis, and autophagy, is altered in several malignancies [128,129,130,131]. This evidence concerns the gene PIK3CA and neoplasm.