Additionally, alpha-1 blockers, commonly used to treat BPH, do not decrease cell proliferation, but work by relaxing prostate smooth muscles to increase urine flow/weak stream; they also have negative side effects (dizziness, lightheadedness, drowsiness, runny/stuff nose and ejaculatory disorders, confusion, and depression) [17]. The gene discussed is PSMA6; the disease is benign prostatic hyperplasia.