The concentration of VEGF-A in HPP and HPS showed approx. a 5-fold increase after 4 days of incubation compared to the baseline level in fresh plasma (plasma vs. HPP: 142.63 vs. 757.00 pg/mL, p < 0.05) and serum (serum vs. HPS: 412.25 vs. 2350.33 pg/mL, p < 0.05) (Figure 2A,B). The gene discussed is VEGFA; the disease is hypophosphatasia.