Indeed, chronic and acute hyperglycemia can trigger platelet activation [26,27], while in diabetic patients, the production of several growth factors involved in initiating and sustaining the healing process is compromised [25]; for example, vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) protein expression is reduced in diabetic dermal wounds [28,29]. Here, VEGFA is linked to Hyperglycemia.