In this study, we quantified 24 total and phosphorylated DDR proteins in CLL patient samples using RPPA and observed that 75% of these proteins had expression levels that were significantly different from normal, with half of the abnormally expressed proteins demonstrating very low expression and the other half showing a heterogenous expression that was both above and below normal. Here, DDR1 is linked to B-cell chronic lymphocytic leukemia.