OSAS is independently correlated with insulin resistance and fatty liver disease, and several genes involved in cholesterol metabolism were impaired, such as malic enzyme and acetyl coenzyme A (CoA) synthetase, or acetyl-CoA carboxylase, stearoyl-CoA desaturases 1 and mitochondrial glycerol- 3-phosphate acyltransferase [61]. This evidence concerns the gene GPAM and Insulin resistance.