Devulapally et al. by exploiting this platform synthesized a biodegradable PLGA/PEI nanoparticles (polyethylene glycol (PEG)ylated-poly (lactic-co-glycolic acid)/polyethyleneimine) complexed to plasmid vectors expressing the HSV1-sr39TK-NTR (TK–NTR) fusion gene under a tumor-specific survivin promoter. Here, NTSR1 is linked to neoplasm.