AKT1 and neoplasm: It was also revealed that the expression of phosphorylated Akt, an indication of the PI3K/Akt pathway activity, was increased in CSCs that were transwell cocultured with PDX or patient primary tumor stromal cells as compared with the controls in which the CSCs were transwell cocultured with mouse normal thyroid or patient non-tumor thyroid tissue-derived stromal cells, respectively (Figure 3A,B).