Particularly in hematological malignancies, there are some examples, such as loss of 13q14 region in CLL, that contain miR-15 and miR-16, which are important regulators of BCL2-mediated apoptosis, leading to a reduced expression or loss of expression [172,173]; the proto-oncogene MYC, frequently altered by chromosomal rearrangements and amplifications, regulates several miRNAs, such as the miR-17-92 cluster, miR-34a, and miR-15a/16-1, and its expression is also controlled by miR-17-92 in a feedback-loop manner [174]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.