The vast majority of almost 170 RyR2 mutations encode for catecholaminergic polymorphic ventricular tachycardia, type 1 (CPVT1) [67,68] and the remaining mutations are mainly associated with arrhythmogenic right ventricular dysplasia, type 2 (ARVC/D2) [69,70] and polymorphic ventricular tachycardia (PVT) [71,72]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia 1.