This conclusion was, however, contradicted by Si et al. [180], who clearly evidenced that RyR2 hyperphosphorylation at S2808, but not at S2814, was essential for the therapeutic effect of azumolene (an active analog of dantrolene) on ischemia- and reperfusion-induced arrhythmias in the rabbit heart model. Here, RYR2 is linked to cardiac arrhythmia.