Coloboma (C) resulted from the failure of the optic fissure to close properly, and Pillai-Kastoori et al. (2014) [21] showed that the transcription factor Sox11 is required to maintain specific levels of Hedgehog signaling during ocular development; once Sox11 has mutated, zebrafish present abnormal ocular formation. The gene discussed is SOX11; the disease is coloboma.