GUCA1C and primary congenital glaucoma: Morales-Cámara et al. (2021) [63] studied the involvement of guanylate cyclase activator 1C (guca1c) in the pathophysiology of primary congenital glaucoma through the generation of a guca1c knocked out zebrafish, which presented cell apoptosis and gliosis, with the Müller cells intensifying the expression of glial fibrillary acidic protein.