Given the specific association of only the IGF2 glycopeptide tPPTVLPDNFPRYP with CKD, predictions that were shared amongst the different IGF2 glycopeptides were disregarded, highlighting Cathepsins, as specifically cleaving glycopeptide tPPTVLPDNFPRYP at the N terminus. Here, IGF2 is linked to chronic kidney disease.