Given the specific association of only the IGF2 glycopeptide tPPTVLPDNFPRYP with CKD, predictions that were shared amongst the different IGF2 glycopeptides were disregarded, highlighting Cathepsins, as specifically cleaving glycopeptide tPPTVLPDNFPRYP at the N terminus. The gene discussed is CTSS; the disease is chronic kidney disease.