The study highlighted the important role of an endoplasmic reticulum protein RTN3 in the IGF2-JAK2-STAT3 pathway, where the reduction in RTN3 in the kidneys results in increased transcription of IGF2, which in turn activates the JAK2-STAT3 pathway, ultimately inducing kidney fibrosis and CKD. The gene discussed is STAT3; the disease is chronic kidney disease.