In brief, associations of increased serum levels of IGF2 with hypoglycaemia [48] as well as of total and free IGF2 (defined as bound or unbound fractions of IGF2 with IGFBPs, respectively) with obesity accompanying Type 2 Diabetes mellitus (T2DM) have been suggested [49]. This evidence concerns the gene IGF2 and obesity due to melanocortin 4 receptor deficiency.