RUNX1 and acute myeloid leukemia: One of the most common chromosomal translocations seen in the M2 subtype AML is t(8;21) (q22;q22), which involves rearrangements of the RUNX1 (previously described as AML1 or CBFA2) [49] and RUNX1T1 (previously described as ETO, AML1T1, CBFA2T1) [49] genes and can lead to the differentiation of leukemic cells into mature neutrophils and eosinophils, and in some cases, myeloblastomas [50].