NOS2 and myeloid sarcoma: However, treatment assays (t > 0) in rats with MS induced by a HFHNCCD supplemented with GSPE also showed less intestinal inflammation, less gene expression of proinflammatory cytokines such as IL-1β and inducible enzymes such as inducible nitric oxide synthase (iNOS) in the ileum [112], and less TNF-α secretion by the duodenum and colon [113].