However, there are some reports on reduced inflammatory responses by Ezh2 blockage through the upregulation of Suppressor of cytokine signaling 3 (Socs3) and the inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway [41] which has been used to reduce the severity of atherosclerosis [42]. Here, SOCS3 is linked to atherosclerosis.