There are mainly three molecular pathway disruptions that lead to CRC pathogenesis: chromosomal instability (CIN), microsatellite instability (MSI) of the CpG island methylation phenotype, and mismatch repair (MMR); translocation has been identified to affect important mechanisms/pathways (WNT, MAPK/PI3K, TP53, and TGF-beta). The gene discussed is PIK3CA; the disease is cervical squamous intraepithelial neoplasia.