TP53 and colorectal carcinoma: In the CRC–PPIN, we found the top 10 nodes as hubs (TP53, AKT1, CTNNB1, EGFR, HRAS, JUN, MAPK3, RHOA, EGF, and KRAS) and the top 10 nodes as bottlenecks (TP53, CTNNB1, AKT1, EGFR, CYCS, RHOA, JUN, HRAS, EGF, and FOS).