In the CRC–PPIN, we found the top 10 nodes as hubs (TP53, AKT1, CTNNB1, EGFR, HRAS, JUN, MAPK3, RHOA, EGF, and KRAS) and the top 10 nodes as bottlenecks (TP53, CTNNB1, AKT1, EGFR, CYCS, RHOA, JUN, HRAS, EGF, and FOS). The gene discussed is FOS; the disease is colorectal carcinoma.