There were a few genes that were only significantly associated with a single craniosynostosis phenotype, including HOXB4 (sagittal), IRX2 (sagittal and male sagittal), MESI1, MEIS2 (metopic), IRX1 (male metopic), ALX1 (metopic and male metopic), HOXB2 (lambdoid), and HOXB3 (lambdoid and male lambdoid). The gene discussed is HOXB3; the disease is craniosynostosis.