IRX1 and craniosynostosis: There were a few genes that were only significantly associated with a single craniosynostosis phenotype, including HOXB4 (sagittal), IRX2 (sagittal and male sagittal), MESI1, MEIS2 (metopic), IRX1 (male metopic), ALX1 (metopic and male metopic), HOXB2 (lambdoid), and HOXB3 (lambdoid and male lambdoid).