PTEN and melanoma: Concordantly, in a BRAFV600E PTEN–/– melanoma mouse model and a KrasLSL-G12D/+ Trp53fl/fl non-small cell lung cancer mouse model, blockage of WNT secretion by ETC-159 or antagonization of WNTs by the anti-FZD-antibody Vantictumab led to an increase of intratumoral CD8+ T cells [169].