Many in vitro and in vivo studies show that in different tumor types, such as colorectal, lung, breast, or hepatocellular cancer, specific WNTs, including WNT1, WNT2, WNT3A, WNT6, WNT8B, WNT7B, and WNT16B, can activate canonical Wnt signaling and support tumor proliferation [43,46,47,48,50,67,69,71,78,92,94,100]. Here, WNT3A is linked to hepatocellular carcinoma.