Many in vitro and in vivo studies show that in different tumor types, such as colorectal, lung, breast, or hepatocellular cancer, specific WNTs, including WNT1, WNT2, WNT3A, WNT6, WNT8B, WNT7B, and WNT16B, can activate canonical Wnt signaling and support tumor proliferation [43,46,47,48,50,67,69,71,78,92,94,100]. This evidence concerns the gene WNT2 and neoplasm.